Suspicions have been raised that talc use contributes to certain types of disease, mainly cancers of the ovaries and lungs. Talc containing asbestos is classified as a group 1 agent (carcinogenic to humans), talc use in the perineal classified as group 2B (possibly carcinogenic to humans) and talc not containing asbestos is classified as group 3 (unclassifiable as to carcinogenicity in humans)(all in the IARC listing). Reviews by Cancer Research UK and the American Cancer Society conclude that some studies have found a link, but other studies have not.
The studies discuss pulmonary issues, lung cancer, and ovarian cancer. One of these, published in 1993, was a US National Toxicology Program report, which found that cosmetic grade talc containing no asbestos-like fibres was correlated with tumor formation in rats forced to inhale talc for 6 hours a day, five days a week over at least 113 weeks. A 1971 paper found particles of talc embedded in 75% of the ovarian tumors studied. Research published in 1995 and 2000 concluded that it was plausible that talc could cause ovarian cancer, but no conclusive evidence was shown. The Cosmetic Ingredient Review Expert Panel concluded in 2015 that talc, in the concentrations currently used in cosmetics, is safe. In 2018, Health Canada issued a warning, advising against inhaling talcum powder or using it in the female perineal area.
Be careful not to inhale or ingest talc particles. Although talc itself does not pose an asbestos hazard, talc ore may contain minerals that do pose asbestos hazards.